Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology.

Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA.
J Virol. 2019 Aug 28;93(18). pii: e00372-19. doi: 10.1128/JVI.00372-19. Print 2019 Sep 15.


Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS.

Jabs DA, Van Natta ML, Trang G, Jones N, Milush JM, Cheu R, Klatt NR, Pak JW, Danis RP, Hunt PW.
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2218-2225. doi: 10.1167/iovs.18-26070.


Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M Jr, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR.

PLoS Pathog. 2019 Apr 11;15(4):e1007672. doi: 10.1371/journal.ppat.1007672. eCollection 2019 Apr.


Brief Report: Hazardous Cannabis Use and Monocyte Activation Among Methamphetamine Users With Treated HIV Infection.

Vidot DC, Manuzak JA, Klatt NR, Pallikkuth S, Roach M, Dilworth SE, Pahwa S, Carrico AW.

J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):361-364. doi: 10.1097/QAI.0000000000002046.


Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.

Jabs DA, Van Natta ML, Trang G, Jones NG, Milush JM, Cheu R, Klatt NR, Danis RP, Hunt PW.
Am J Ophthalmol. 2019 Mar;199:230-237. doi: 10.1016/j.ajo.2018.12.002. Epub 2018 Dec 12.


CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.

Shah SV, Manickam C, Ram DR, Kroll K, Itell H, Permar SR, Barouch DH, Klatt NR, Reeves RK.

Cell Rep. 2018 Dec 4;25(10):2766-2774.e3. doi: 10.1016/j.celrep.2018.11.020.


Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection.

Guillén Y, Noguera-Julian M, Rivera J, Casadellà M, Zevin AS, Rocafort M, Parera M, Rodríguez C, Arumí M, Carrillo J, Mothe B, Estany C, Coll J, Bravo I, Herrero C, Saz J, Sirera G, Torrella A, Navarro J, Crespo M, Negredo E, Brander C, Blanco J, Calle ML, Klatt NR, Clotet B, Paredes R. Mucosal Immunol. 2019 Jan;12(1):232-246. doi: 10.1038/s41385-018-0083-7. Epub 2018 Aug 31.


Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.

Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.


Intestinal damage precedes mucosal immune dysfunction in SIV infection.

Hensley-McBain T, Berard AR, Manuzak JA, Miller CJ, Zevin AS, Polacino P, Gile J, Agricola B, Cameron M, Hu SL, Estes JD, Reeves RK, Smedley J, Keele BF, Burgener AD, Klatt NR. Mucosal Immunol. 2018 Sep;11(5):1429-1440. doi: 10.1038/s41385-018-0032-5. Epub 2018 Jun 15.


Microbial Effects on Immunity in HIV: Virus, Gender or Sexual Preference Induced?

Klatt NR, Manuzak JA.EBioMedicine. 2018 Apr 7. pii: S2352-3964(18)30136-1. doi: 10.1016/j.ebiom.2018.04.008.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871.


Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

Manuzak JA, Gott TM, Kirkwood JS, Coronado E, Hensley-McBain T, Miller C, Cheu RK, Collier AC, Funderburg NT, Martin JN, Wu MC, Isoherranen N, Hunt PW, Klatt NR.Clin Infect Dis. 2018 Feb 17. doi: 10.1093/cid/cix1116.


The Dual Role of Neutrophils in HIV Infection.

Hensley-McBain T, Klatt NR. Curr HIV/AIDS Rep. 2018 Feb;15(1):1-10. doi: 10.1007/s11904-018-0370-7. Review.


Antibiotic treatment disrupts bacterial communities in the colon and rectum of simian immunodeficiency virus-infected macaques.

Zevin AS, Hensley-McBain T, Miller C, Smith E, Langevin S, Klatt NR. FEMS Microbiol Lett. 2017 Dec 15;364(23). doi: 10.1093/femsle/fnx228.


MicroRNAs: novel tools to block gut inflammation in HIV?

Klatt NR, Hunt PW.AIDS. 2017 Sep 10;31(14):2017-2018. doi: 10.1097/QAD.0000000000001609.


Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women 

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR,

Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.


Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys.

Ortiz AM, Carnathan DG, Yu J, Sheehan KM, Kim P, Reynaldi A, Vanderford TH, Klatt NR, Brenchley JM, Davenport MP, Silvestri G.

PLoS One. 2016 May 26;11(5):e0156352. doi: 10.1371/journal.pone.0156352. eCollection 2016.


Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.

Hensley-McBain T, Zevin AS, Manuzak J, Smith E, Gile J, Miller C, Agricola B, Katze M, Reeves RK, Kraft CS, Langevin S, Klatt NR.

J Virol. 2016 Apr 29;90(10):4981-9. doi: 10.1128/JVI.00099-16. Print 2016 May 15.


Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

Manuzak JA, Hensley-McBain T, Zevin AS, Miller C, Cubas R, Agricola B, Gile J, Richert-Spuhler L, Patilea G, Estes JD, Langevin S,

Reeves RK, Haddad EK, Klatt NR. J Immunol. 2016 Mar 1;196(5):2401-9. doi: 10.4049/jimmunol.1502470. Epub 2016 Jan 29.


Microbial translocation and microbiome dysbiosis in HIV-associated immune activation.

Zevin AS, McKinnon L, Burgener A, Klatt NR. Curr Opin HIV AIDS. 2016 Mar;11(2):182-90. doi: 10.1097/COH.0000000000000234.


Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y,

Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Cell Rep. 2015 Nov 24;13(8):1589-97.

doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.


Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.

Hao XP, Lucero CM, Turkbey B, Bernardo ML, Morcock DR, Deleage C, Trubey CM, Smedley J, Klatt NR, Giavedoni LD, Kristoff J, Xu

A, Del Prete GQ, Keele BF, Rao SS, Alvord WG, Choyke PL, Lifson JD, Brenchley JM, Apetrei C, Pandrea I, Estes JD. Nat Commun.

2015 Aug 18;6:8020. doi: 10.1038/ncomms9020.


SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.

Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK. J Infect Dis. 2016 Feb 1;213(3):361-9.

doi: 10.1093/infdis/jiv404. Epub 2015 Aug 3.


HIV and mucosal barrier interactions: consequences for transmission and pathogenesis.

Burgener A, McGowan I, Klatt NR. Curr Opin Immunol. 2015 Oct;36:22-30. doi: 10.1016/j.coi.2015.06.004. Epub 2015 Jul 4. Review.


Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.

Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, Keele BF, Klatt NR, Reeves RK. PLoS Pathog. 2014 Dec

11;10(12):e1004551. doi: 10.1371/journal.ppat.1004551. eCollection 2014 Dec.


Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN,

Deeks SG, Sinclair E, Hecht FM, Lederman MM, Paiardini M, Kirchhoff F, Brenchley JM, Hunt PW, Silvestri G. PLoS Pathog. 2014 Aug

28;10(8):e1004345. doi: 10.1371/journal.ppat.1004345. eCollection 2014 Aug.