The Klatt Lab

With more than 30 million individuals infected with HIV worldwide, the need for more effective prevention or intervention strategies is crucial. The Klatt lab focuses on mucosal immunology as well as understanding the microbiome relative factors important in HIV infection. We utilize both human samples as well as the non-human primate model of HIV, simian immunodeficiency virus (SIV) infection of macaques, for our studies. It is our mission to keep our research fluid and ever expanding, to always be contributing to the advancements in research. 

News!

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Gut bacteria feast on the pills we pop

“Mounting data raise the question: How will drug firms respond?”

August 31, 2019

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Longer neutrophil lifespan may contribute to HIV-associated intestinal inflammation

”The increased survival of white blood cells called neutrophils is associated with alterations in the intestinal microbiome of HIV-infected individuals, according to a new study.”
April 11, 2019


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Vaginal Microbiome May Influence Effectiveness of Pre-Exposure Prophylaxis

“Over 1 million women are infected with HIV on an annual basis. To reduce this number, more understanding is needed. Even after decades of research, not much is known about the biological mechanisms that lead to HIV acquisition in this population.”
March 7, 2018

Unhealthy vagina microbiome can make HIV drugs less effective | Bob Roher | New Scientist

"The balance of bacterial strains living in the vagina can influence how effective a medicated gel is at protecting against HIV"
June 1, 2017

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Women's bacteria thwarted attempt at anti-HIV vaginal gel | Lauran Neergaard | The Washington Post            

"We have to look at biological variability in each person."
June 1, 2017

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Vaginal bacteria species can raise HIV infection risk and undermine prevention | Jon Cohen | Science

"Showed that the vaginal microbiome doesn’t just influence infection risk; it can also directly interfere with PrEP." 

July 18, 2016

UW team finding is integral to HIV drug-effectiveness puzzle | Sarah C.B. Guthrie | NewsBeat
"Pharmacy researchers detect bacteria that counteracts protective drug."
July 19, 2016