Microbial Effects on Immunity in HIV: Virus, Gender or Sexual Preference Induced?

Klatt NR, Manuzak JA.EBioMedicine. 2018 Apr 7. pii: S2352-3964(18)30136-1. doi: 10.1016/j.ebiom.2018.04.008.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871.


Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

Manuzak JA, Gott TM, Kirkwood JS, Coronado E, Hensley-McBain T, Miller C, Cheu RK, Collier AC, Funderburg NT, Martin JN, Wu MC, Isoherranen N, Hunt PW, Klatt NR.Clin Infect Dis. 2018 Feb 17. doi: 10.1093/cid/cix1116.


The Dual Role of Neutrophils in HIV Infection.

Hensley-McBain T, Klatt NR. Curr HIV/AIDS Rep. 2018 Feb;15(1):1-10. doi: 10.1007/s11904-018-0370-7. Review.


Antibiotic treatment disrupts bacterial communities in the colon and rectum of simian immunodeficiency virus-infected macaques.

Zevin AS, Hensley-McBain T, Miller C, Smith E, Langevin S, Klatt NR. FEMS Microbiol Lett. 2017 Dec 15;364(23). doi: 10.1093/femsle/fnx228.


MicroRNAs: novel tools to block gut inflammation in HIV?

Klatt NR, Hunt PW.AIDS. 2017 Sep 10;31(14):2017-2018. doi: 10.1097/QAD.0000000000001609.


Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women 

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR,

Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.


Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys.

Ortiz AM, Carnathan DG, Yu J, Sheehan KM, Kim P, Reynaldi A, Vanderford TH, Klatt NR, Brenchley JM, Davenport MP, Silvestri G.

PLoS One. 2016 May 26;11(5):e0156352. doi: 10.1371/journal.pone.0156352. eCollection 2016.


Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.

Hensley-McBain T, Zevin AS, Manuzak J, Smith E, Gile J, Miller C, Agricola B, Katze M, Reeves RK, Kraft CS, Langevin S, Klatt NR.

J Virol. 2016 Apr 29;90(10):4981-9. doi: 10.1128/JVI.00099-16. Print 2016 May 15.


Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

Manuzak JA, Hensley-McBain T, Zevin AS, Miller C, Cubas R, Agricola B, Gile J, Richert-Spuhler L, Patilea G, Estes JD, Langevin S,

Reeves RK, Haddad EK, Klatt NR. J Immunol. 2016 Mar 1;196(5):2401-9. doi: 10.4049/jimmunol.1502470. Epub 2016 Jan 29.


Microbial translocation and microbiome dysbiosis in HIV-associated immune activation.

Zevin AS, McKinnon L, Burgener A, Klatt NR. Curr Opin HIV AIDS. 2016 Mar;11(2):182-90. doi: 10.1097/COH.0000000000000234.


Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y,

Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Cell Rep. 2015 Nov 24;13(8):1589-97.

doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.


Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.

Hao XP, Lucero CM, Turkbey B, Bernardo ML, Morcock DR, Deleage C, Trubey CM, Smedley J, Klatt NR, Giavedoni LD, Kristoff J, Xu

A, Del Prete GQ, Keele BF, Rao SS, Alvord WG, Choyke PL, Lifson JD, Brenchley JM, Apetrei C, Pandrea I, Estes JD. Nat Commun.

2015 Aug 18;6:8020. doi: 10.1038/ncomms9020.


SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.

Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK. J Infect Dis. 2016 Feb 1;213(3):361-9.

doi: 10.1093/infdis/jiv404. Epub 2015 Aug 3.


HIV and mucosal barrier interactions: consequences for transmission and pathogenesis.

Burgener A, McGowan I, Klatt NR. Curr Opin Immunol. 2015 Oct;36:22-30. doi: 10.1016/j.coi.2015.06.004. Epub 2015 Jul 4. Review.


Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.

Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, Keele BF, Klatt NR, Reeves RK. PLoS Pathog. 2014 Dec

11;10(12):e1004551. doi: 10.1371/journal.ppat.1004551. eCollection 2014 Dec.


Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN,

Deeks SG, Sinclair E, Hecht FM, Lederman MM, Paiardini M, Kirchhoff F, Brenchley JM, Hunt PW, Silvestri G. PLoS Pathog. 2014 Aug

28;10(8):e1004345. doi: 10.1371/journal.ppat.1004345. eCollection 2014 Aug.